Tulopafant


CAS No. : 116289-53-3

(Synonyms: RP 59227)

116289-53-3
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Cat. No. : HY-101594
M.Wt: 425.50
Formula: C25H19N3O2S
Purity: >98 %
Solubility: 10 mM in DMSO
Introduction of 116289-53-3 :

Tulopafant is a platelet activating factor (PAF) antagonist. In Vitro: Preincubation of neutrophils with Tulopafant (RP 59227) results in a concentration-dependent decrease in chemiluminescence produced by PAF primed cells[1]. In Vivo: Tulopafant (RP 59227) effectively reduces myocardial infarct size and reduces the incidence of ischemia and reperfusion-induced arrhythmias in barbital-anesthetized dogs[1].Histological examination reveals marked diminution of both interstitial hemorrhage and deposition of platelet and granulocytes in capillaries of cardiac xenografts when recipient animals are pretreated with Tulopafant[2].

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