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Cat. No. : | HY-101594 |
M.Wt: | 425.50 |
Formula: | C25H19N3O2S |
Purity: | >98 % |
Solubility: | 10 mM in DMSO |
Tulopafant is a platelet activating factor (PAF) antagonist. In Vitro: Preincubation of neutrophils with Tulopafant (RP 59227) results in a concentration-dependent decrease in chemiluminescence produced by PAF primed cells[1]. In Vivo: Tulopafant (RP 59227) effectively reduces myocardial infarct size and reduces the incidence of ischemia and reperfusion-induced arrhythmias in barbital-anesthetized dogs[1].Histological examination reveals marked diminution of both interstitial hemorrhage and deposition of platelet and granulocytes in capillaries of cardiac xenografts when recipient animals are pretreated with Tulopafant[2].
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