HLCL-61 (hydrochloride)


CAS No. : 1158279-20-9

1158279-20-9
Price and Availability of CAS No. : 1158279-20-9
Size Price Stock
10mg $108 In-stock
25mg $180 In-stock
50mg $300 In-stock
100mg $540 In-stock
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Cat. No. : HY-100025A
M.Wt: 380.91
Formula: C23H25ClN2O
Purity: >98 %
Storage: at 20℃ 2 years
Solubility: DMSO: ≥ 30 mg/mL
Introduction of 1158279-20-9 :

HLCL-61 hydrochloride is a first-in-class small-molecule inhibitor of PRMT5. Target: PRMT5 in vitro: HLCL-61 shows effective inhibition of symmetric arginine dimethylation (me2) of histones H3 and H4 in AML samples, starting at 12 h post-treatment and persisting after 48 h. Treatment of AML cell lines (MV4-11 and THP-1) and primary blasts with HLCL-61 also resulted in a decrease of cell viability. HLCL-61 is also effective in promoting apoptosis in MV4-11 and THP-1 cells after 48 h.[1]

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