(E/Z)-J147
CAS No. : 1146963-51-0
| Size | Price | Stock |
|---|---|---|
| 5mg | $50 | In-stock |
| 10mg | $70 | In-stock |
| 25mg | $110 | In-stock |
| 50mg | $160 | In-stock |
| 100mg | $240 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
| We match the lowest price on market. | ||
We offer a substantial discount on larger orders, please inquire via [email protected]
or Fax: (86)21-58955996
Inquiry for price and availability only. Please place your order via our email or fax.
| Cat. No. : | HY-13779 |
| M.Wt: | 350.34 |
| Formula: | C18H17F3N2O2 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL |
(E/Z)-J147 is an exceptionally potent, orally active, neuroprotective agent for cognitive enhancement. (E/Z)-J147 can readily pass the blood brain barrier (BBB). (E/Z)-J147 can inhibit monoamine oxidase B (MAO B) and the dopamine transporter with EC50 values of 1.88 μM and 0.649 μM, respectively. (E/Z)-J147 has potential for the treatment of Alzheimer’s disease (AD)[1][2][3].
IC50 & Target:MAO B; Dopamine transporter[2]
In Vitro:(E/Z)-J147 promotes HT22 and primary cell survival in a dose-dependent manner (EC50 value range of 0.06-0.115 μM) [2].
In Vivo:(E/Z)-J147 (diet is prepared by the addition of (E/Z)-J147 at 200ppm; 6 months) enhances memory and dendritic spine number in old mice[4].
The half life (t1/2) of (E/Z)-J147 is calculated at 1.5 hrs in plasma and 2.5 hrs in brain ( per oral (PO) administration at a single dose of 20 mg/kg)[2].
Lorem ipsum dolor sit amet, consectetur adipisicing elit. Autem earum hic iste maiores, nam neque rem suscipit. Adipisci consequatur error exercitationem fugit ipsam optio qui, quibusdam repellendus sed vero! Debitis.
Inquiry Information- Product Name:
- (E/Z)-J147
- Cat. No.:
- HY-13779
- Quantity:
Your information is safe with us.