FAAH-IN-6


CAS No. : 1143578-94-2

1143578-94-2
Price and Availability of CAS No. : 1143578-94-2
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Cat. No. : HY-103461
M.Wt: 397.38
Formula: C19H17F2N7O
Purity: >98 %
Solubility: 10 mM in DMSO
Introduction of 1143578-94-2 :

FAAH-IN-6 (compound 21d) is a potent, orally active and cross the blood-brain barrier fatty acid amide hydrolase (FAAH) inhibitor with IC50s of 0.72, 0.28 nM for hFAAH, rFAAH, respectively. FAAH-IN-6 shows dose-dependent analgesic efficacy in animal models of both neuropathic and inflammatory pain[1]. IC50 & Target: IC50: 0.72 nM (hFAAH); 0.28 nM (rFAAH)[1] In Vivo: FAAH-IN-6 (compound 21d) (1-10 mg/kg; p.o.) shows significantly ameliorates tactile allodynia in a dose-dependent fashion in SNI-induced neuropathic pain rats model[1].
FAAH-IN-6 (3-10 mg/kg; p.o.) shows significantly ameliorates tactile allodynia of the ipsilateral hind paw in CFA-induced inflammatory pain model[1].

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