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HY-10001

CAS:112965-21-6

 (Synonyms  MC 903;Calcipotriene)
112965-21-6  Technical Data: Price and Availability of  Cas No:112965-21-6

Cas : 112965-21-6 M.Wt: 412.6047
Cas : 112965-21-6 Formula: C27H40O3
Cas : 112965-21-6 Purity: >98 %
Cas : 112965-21-6 Storage: at 20℃ 2 years
Cas : 112965-21-6 Solubility: 10 mM in DMSO
Cas : 112965-21-6 Name: Calcipotriol
USD
5mg/$50 In-stock
10mg/$70 In-stock
50mg/$240 In-stock
100mg/$440 In-stock
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112965-21-6  Data Sheet:
 
Introduction of 112965-21-6 :
Calcipotriol is a synthetic VitD3 analogue with a high affinity for the vitamin D receptor. IC50 & Target: Vitamin D receptor[1] In Vitro: When NHEK cells are not stimulated with IL-17A or IL-22, Calcipotriol slightly enhances (0.2 nM) IL-8 mRNA expression or has no effect (2-20 nM). The addition of IL-17A and IL-22 markedly increased the mRNA expression of IL-8, confirming our previous study. This enhanced IL-8 mRNA expression is suppressed by Calcipotriol at 2, 20 and 40 nM in a dose dependent manner[1]. Treatment of natural killer (NK) cells with drugs modulates their expression of NK cytotoxicity receptors or KIR. Human NK cells are pre-treated with 100, 10 or 1 ng/mL of 1,25(OH)2D3, Calcipotriol or FTY720 for 4 h. All three concentrations of 1,25(OH)2D3, Calcipotriol and FTY720 significantly up-regulate the expression of NKp30 on the surface of NK cells after 4 h incubation[2]. In Vivo: One out of the 32 animals in each of the groups has died, except for the Diclofenac plus DFMO plus Calcipotriol group, where all animals survived. Survival is equally distributed between the groups. The weight gain is significantly smaller in the groups treated with Diclofenac plus Calcipotriol (p=0.018) and Diclofenac plus DFMO plus Calcipotriol (p=0.002) compare with placebo (linear regression model)[3].
 
References on 112965-21-6 :
 

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