JNJ-40411813
CAS No. : 1127498-03-6
(Synonyms: ADX-71149)
| Size | Price | Stock |
|---|---|---|
| 5mg | $250 | In-stock |
| 10mg | $390 | In-stock |
| 50mg | $930 | In-stock |
| 100mg | $1250 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-15748 |
| M.Wt: | 344.88 |
| Formula: | C20H25ClN2O |
| Purity: | >98 % |
| Solubility: | DMSO : 25 mg/mL (ultrasonic) |
JNJ-40411813 (ADX-71149) is a novel positive allosteric modulator of the metabotropic Glutamate 2 receptor (mGlu2R) with EC50 of 147 nM. JNJ-40411813 has orally bioactivity and penetrate the blood-brain barriers. JNJ-40411813 has the potential property of anti-depression[1][2][3].
In Vivo:JNJ-40411813 (ADX-71149) (5-20 mg/kg; p.o.; 6 times in 24 h) clearly potentiated glutamate response in brain regions, more specifically in the cortical regions, striatum, and the hippocampus, coaddition of Glutamate (HY-N0455B)[2].
Pharmacokinetic Analysis in SD rat[2]
| Route | Dose (mg/kg) | AUCINF_obs (ng·h/mL) | t1/2 (h) | Tmax (h) | Cmax (ng/mL) | Clobs (L·h/kg) | Vss_obs (L/kg) |
| i.v. | 2.5 | 1833±90 | / | / | / | 1.4±0.1 | 2.31.4±0.10.2 |
| p.o. | 10 | 2250±417 | 2.31±0.5 | 7 | 938 | / | / |
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