WAY-100635 (maleate)


CAS No. : 1092679-51-0

1092679-51-0
Price and Availability of CAS No. : 1092679-51-0
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Cat. No. : HY-10349A
M.Wt: 538.64
Formula: C29H38N4O6
Purity: >98 %
Solubility: H2O : 25 mg/mL (46.41 mM; Need ultrasonic); DMSO : ≥ 250 mg/mL (464.13 mM)
Introduction of 1092679-51-0 :

WAY-100635 maleate is a potent and selective 5-hydroxytryptamine 1A (5-HT1A) receptor antagonist with an IC50 value of 0.91 nM and Ki value of 0.39 nM. WAY-100635 maleate has pIC50 values for 5-HT1A and α1-adrenergic receptors of 8.9 and 6.6, respectively. WAY-100635 maleate is also a potent dopamine D4 receptor agonist[1][2][3]. IC50 & Target:pIC50 Value: 8.87 (5-HT1A Receptor)[1]. In Vitro: The functional properties and binding affinities of WAY-100635 are evaluated in HEK 293 cells stably expressing dopamine D2L or D4.4 receptors[1].
WAY-100635 displays 940, 370, and 16 nM binding affinities at D2L, D3, and D4.2 receptors, respectively. Saturation analyses demonstrat that the Kd of [3H] WAY-100635 at D4.2 receptors is 2.4 nM. WAY-100635 is potent agonist in HEK-D4.4 cells with EC50 of 9.7 nM. WAY-100635 possesses high affinity for D4.4 receptor (3.3 nM) [1]. In Vivo: WAY-100635 (1 mg/kg; subcutaneous injection; male Sprague-Dawley rats) treatment abolishes the reduction of the severity of abstinence signs induced by Rhodiola rosea administration in nicotine-dependent rat[2].

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