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HY-11002

CAS:1080622-86-1

 (Synonyms  CP466722;CP 466722)
1080622-86-1  Technical Data: Price and Availability of  Cas No:1080622-86-1

Cas : 1080622-86-1 M.Wt: 349.35
Cas : 1080622-86-1 Formula: C17H15N7O2
Cas : 1080622-86-1 Purity: >98 %
Cas : 1080622-86-1 Storage: at 20℃ 2 years
Cas : 1080622-86-1 Solubility: DMSO: 0.28 mg/mL, H2O: <1 mg/mL
Cas : 1080622-86-1 Name: CP-466722
USD
5mg/$90 In-stock
10mg/$150 In-stock
50mg/$420 In-stock
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5g Get quote
>10g Get quote
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1080622-86-1  Data Sheet:
 
Introduction of 1080622-86-1 :
CP-466722 is rapidly reversible potential ATM kinase inhibitor. IC50 Value: Target: ATM CP-466722 is non-toxic and does not inhibit PI3K or PI3K-like protein kinase family members in cells. CP-466722 inhibited cellular ATM-dependent phosphorylation events and disruption of ATM function resulted in characteristic cell cycle checkpoint defects. Inhibition of cellular ATM kinase activity was rapidly and completely reversed by removing CP-466722. Interestingly, clonogenic survival assays demonstrated that transient inhibition of ATM is sufficient to sensitize cells to ionizing radiation and suggests that therapeutic radiosensitization may only require ATM inhibition for short periods of time. The ability of CP-466722 to rapidly and reversibly regulate ATM activity provides a new tool to ask questions about ATM function that could not easily be addressed using genetic models or RNA interference technologies.
 
References on 1080622-86-1 :
 

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