CP-466722


CAS No. : 1080622-86-1

1080622-86-1
Price and Availability of CAS No. : 1080622-86-1
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5mg $108 In-stock
10mg $180 In-stock
50mg $504 In-stock
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Cat. No. : HY-11002
M.Wt: 349.35
Formula: C17H15N7O2
Purity: >98 %
Storage: at 20℃ 2 years
Solubility: DMSO: 7 mg/mL (Need warming)
Introduction of 1080622-86-1 :

CP-466722 is a rapidly reversible inhibitor of ATM, with an IC50 of 4.1 μM, and has no effects on PI3K or closely related PI3K-like protein kinase (PIKK) family members. IC50 & Target: IC50: 4.1 μM (ATM)[2] In Vitro: CP-466722 (CP466722, 6-10 μM) inhibits IR-induced ATM kinase activity, and the inhibition can be rapidly and completely reversed. CP466722 (6, 10 μM) inhibits p53 induction and ATM-dependent phosphorylation in mouse cells, but CP466722 fails to inhibit ATR activity and ATR-dependent phosphorylation of Chk1. CP466722 (6 μM) disrupts ATM-dependent cell cycle checkpoints in cells[1]. CP466722 (1 ?M) completely inhibits ATM-dependent phosphorylation in MCF7 cells. CP466722 (10 ?M) reduces pKAP1 phosphorylation in MCF7 cells, with an IC50 of 0.41 ?M. CP466722 (10 ?M) inhibits both pATM and pKAP1 signals[2]. CP-466722 (CP466722, 5-50 μM) inhibits proliferation of SKBr-3 cancer cells more strongly than MCF-7 cancer cells. CP466722 (10 ?M) also slightly increases proportions of MCF-7 and SKBr-3 cells in the G1 phase after treatment for 48 hours[3].

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