E-mail  
Home
 
AboutUs
 
Service
 
Products
 
Order Information
 
Contact us
Insert title here
Featured Products
HY-10005  |  Flavopiridol
HY-10008  |  SNS-032
HY-10012  |  AZD-5438
HY-10014  |  R547
HY-10032  |  PF 477736
HY-10087  |  Navitoclax
HY-10128  |  ZM-447439
HY-10161  |  Tozasertib
HY-10180  |  MLN8054
HY-10192  |  NVP-TAE 684
HY-10228  |  Motesanib
HY-10249  |  GSK-690693
HY-10355  |  AKT inhibitor VIII
HY-10358  |  MK 2206 (dihydrochloride)
HY-10992  |  AZD-7762
HY-10997  |  PCI-32765
HY-11001  |  PHA-793887
HY-11002  |  CP-466722
HY-11007  |  GNF-2
HY-11009  |  CGP60474
more    
Products
HY-100868

CAS:1037592-40-7

 (Synonyms  KYT-0353)
1037592-40-7  Technical Data: Price and Availability of  Cas No:1037592-40-7

Cas : 1037592-40-7 M.Wt: 472.32066
Cas : 1037592-40-7 Formula: C23H19Cl2N3O4
Cas : 1037592-40-7 Purity: >98 %
Cas : 1037592-40-7 Storage: at 20℃ 2 years
Cas : 1037592-40-7 Solubility: 10 mM in DMSO
Cas : 1037592-40-7 Name: JPH203
Please check here to inquiry for availability and price .

 
1037592-40-7  Data Sheet:
 
Introduction of 1037592-40-7 :
JPH203 is a potent and selective L-type amino acid transporter 1 inhibitor (LAT1), used for cancer research. In Vitro: JPH203 inhibits 14C-leucine uptake and cell growth in human colon cancer-derived HT-29 cells; IC50s are 0.06 μM and 4.1 μM, respectively. JPH203 also inhibits 14C-leucine uptake in mouse renal proximal tubule cells expressing l-type amino acid transporter 1, and inhibits cell growth; IC50s are 0.14 μM and 16.4 μM, respectively[1]. Growth dose response demonstrates an extreme sensitivity of CD98KO cells to JPH203 with an IC50 of 1.0 μM, whereas the IC50 for WT cells is 35-fold higher. Furthermore, 5.0 μM of JPH203 completely abolishes the growth of CD98KO cells. JPH203 treatment increases the GCN2 pathway, reduces mTORC1 activity, and inhibits proliferation in all of the cell lines tested[2]. JPH203 (0.001-100 μM) inhibits the [14C]L-leucine (1.0 mM) uptake slightly in the NHOKs. JPH203 (0.01-30 mM) completely inhibits the proliferation of YD-38 cells in a dose- and time-dependent manner[3]. In Vivo: JPH203 (12.5 mg/kg and 25.0 mg/kg, i.v.) shows statistically significant growth inhibition against HT-29 tumors transplanted to nude mice with maximal inhibition ratios of 65.9% and 77.2%, respectively[1].
 
References on 1037592-40-7 :
 

Keywords: buy JPH203 | JPH203 Supplier | purchase JPH203 | JPH203 cost | JPH203 manufacturer | order JPH203 | JPH203 distributor | JPH203 structure
buy 1037592-40-7 | 1037592-40-7 Supplier | purchase 1037592-40-7 | 1037592-40-7 cost | 1037592-40-7 manufacturer | order 1037592-40-7 | 1037592-40-7 distributor | 1037592-40-7 structure
Insert title here
 
Products are for research use only. Not for human use. We do not sell to patients.           Copyright © 2009 Haoyuan Chemexpress All Rights Reserved
ADDRESS: 6/F, No. 2 Building, No. 720,Cailun Road, Shanghai, P.R.China  
TEL:
86-21-58998590   FAX: 86-21-53700326, 86-21-58998590   E-mail: sales@chemexpress.cn