Jasplakinolide
CAS No. : 102396-24-7
| Size | Price | Stock |
|---|---|---|
| 50μg | $450 | Get quote |
| 100μg | $720 | Get quote |
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| Cat. No. : | HY-P0027 |
| M.Wt: | 709.67 |
| Formula: | C36H45BrN4O6 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Jasplakinolide is a potent actin polymerization inducer and stabilizes pre-existing actin filaments. Jasplakinolide binds to F-actin competitively with phalloidin with a Kd of 15 nM. Jasplakinolide, a naturally occurring cyclic peptide from the marine sponge, has both fungicidal and anti-cancer activity[1][2].
In Vitro: Jasplakinolide has an IC50 of 35 nM for the antiproliferative effect of jasplakinolide on PC3 prostate carcinoma cells[2].
Jasplakinolide (10 μM; for 2 hours) generates binucleated cells when applied during mitosis. Jasplakinolide induces the formation of F-actin-containing apical extensions in Toxoplasma gondii tachyzoites[2].
Jasplakinolide (1 mM; for 60 min) induces the formation of actin-containing apical extensions in isolated Toxoplasma gondii tachyzoites fixed[2].
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