TC ASK 10
CAS No. : 1005775-56-3
| Size | Price | Stock |
|---|---|---|
| 1mg | $166 | In-stock |
| 5mg | $350 | In-stock |
| 10mg | $550 | In-stock |
| 25mg | $1060 | In-stock |
| 50mg | $1550 | In-stock |
| 100mg | $2300 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-103258 |
| M.Wt: | 432.35 |
| Formula: | C21H23Cl2N5O |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (231.29 mM; Need ultrasonic) |
TC ASK 10 (Compound 10) is a potent, selective and orally active apoptosis signal-regulating kinase 1 (ASK1) inhibitor with an IC50 of 14 nM. The inhibitory activities of TC ASK 10 towards other representative panel of kinases are less than 50%, except for ASK2 (IC50 of 0.51 μM)[1]. In Vitro: TC ASK 10 (Compound 10; 0-10 μM; 1 hour; INS-1 cells) treatment inhibits streptozotocin (STZ)-induced JNK in INS-1 pancreatic β cells from 0.3 μM. Phosphorylation of p38 is also inhibited in a dosedependent manner[1]. In Vivo: Pharmacokinetic profiles in rats are tested. TC ASK 10 (Compound 10•HCl; rat cassette doing at 0.1 mg/kg, iv and 1 mg/kg, po.) has a good oral bioavailability. The Cmax, Tmax and AUCpo,0-8h are 285.1 ng/mL, 1.67 h and 275.4 ng.h/mL, respectively for TC ASK 10[1].
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